Increased prevalence of diastolic dysfunction in rheumatoid arthritis
Identifieur interne : 001641 ( Main/Exploration ); précédent : 001640; suivant : 001642Increased prevalence of diastolic dysfunction in rheumatoid arthritis
Auteurs : Kimberly P. Liang [États-Unis] ; Elena Myasoedova [États-Unis] ; Cynthia S. Crowson [États-Unis] ; John M. Davis [États-Unis] ; Véronique L. Roger [États-Unis] ; Barry L. Karon [États-Unis] ; Daniel D. Borgeson [États-Unis] ; Terry M. Therneau [États-Unis] ; Richard J. Rodeheffer [États-Unis] ; Sherine E. Gabriel [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2010-09.
English descriptors
- Teeft :
- Abnormality, Antirheumatic drugs, Arterial pressure, Arthritis, Arthritis rheum, Atrial, Atrial contraction, Atrial volume index, Biological agents, Blood pressure, Clin, Clin rheumatol, Cohort, Congestive heart failure, Diabetes mellitus, Diastolic, Diastolic blood pressure, Diastolic dysfunction, Diastolic function, Diastolic function abnormalities, Disease characteristics, Dmards, Doppler, Drug usage, Dysfunction, Echocardiographic, Echocardiography, Echocardiography visit, Further investigation, Heart failure, Higher prevalence, Hypertension, Lling, Lling pressures, Lling velocity, Mass index, Mayo, Mayo clinic, Mayo clinic college, Methotrexate, Mitral peak, Myocardial function, Ndings, Olmsted county, Other dmards, Previous studies, Rheum, Rheumatoid, Rheumatoid arthritis, Rheumatol, Risk factors, Tricuspid regurgitant, Vast majority, Ventricular, Ventricular function.
Abstract
Objective To compare the prevalence of left ventricular (LV) diastolic dysfunction in subjects with and without rheumatoid arthritis (RA), among those with no history of heart failure (HF), and to determine risk factors for diastolic dysfunction in RA. Methods A cross-sectional, community-based study comparing cohorts of adults with and without RA and without a history of HF was carried out. Standard two-dimensional/Doppler echocardiography was performed in all participants. Diastolic dysfunction was defined as impaired relaxation (with or without increased filling pressures) or advanced reduction in compliance or reversible or fixed restrictive filling. Results The study included 244 subjects with RA and 1448 non-RA subjects. Mean age was 60.5 years in the RA cohort (71% female) and 64.9 years (50% female) in the non-RA cohort. The vast majority (>98%) of both cohorts had preserved ejection fraction (EF≥50%). Diastolic dysfunction was more common in subjects with RA at 31% compared with 26% (age and sex adjusted) in non-RA subjects (OR=1.6; 95% CI 1.2 to 2.4). Patients with RA had significantly lower LV mass, higher pulmonary arterial pressure and higher left atrial volume index than non-RA subjects. RA duration and interleukin 6 (IL-6) level were independently associated with diastolic dysfunction in RA even after adjustment for cardiovascular risk factors. Conclusion Subjects with RA have a higher prevalence of diastolic dysfunction than those without RA. RA duration and IL-6 are independently associated with diastolic dysfunction, suggesting the impact of chronic autoimmune inflammation on myocardial function in RA. Clinical implications of these findings require further investigation.
Url:
DOI: 10.1136/ard.2009.124362
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002973
- to stream Istex, to step Curation: 002973
- to stream Istex, to step Checkpoint: 000586
- to stream Main, to step Merge: 001644
- to stream Main, to step Curation: 001641
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Increased prevalence of diastolic dysfunction in rheumatoid arthritis</title><author><name sortKey="Liang, Kimberly P" sort="Liang, Kimberly P" uniqKey="Liang K" first="Kimberly P" last="Liang">Kimberly P. Liang</name></author><author><name sortKey="Myasoedova, Elena" sort="Myasoedova, Elena" uniqKey="Myasoedova E" first="Elena" last="Myasoedova">Elena Myasoedova</name></author><author><name sortKey="Crowson, Cynthia S" sort="Crowson, Cynthia S" uniqKey="Crowson C" first="Cynthia S" last="Crowson">Cynthia S. Crowson</name></author><author><name sortKey="Davis, John M" sort="Davis, John M" uniqKey="Davis J" first="John M" last="Davis">John M. Davis</name></author><author><name sortKey="Roger, Veronique L" sort="Roger, Veronique L" uniqKey="Roger V" first="Véronique L" last="Roger">Véronique L. Roger</name></author><author><name sortKey="Karon, Barry L" sort="Karon, Barry L" uniqKey="Karon B" first="Barry L" last="Karon">Barry L. Karon</name></author><author><name sortKey="Borgeson, Daniel D" sort="Borgeson, Daniel D" uniqKey="Borgeson D" first="Daniel D" last="Borgeson">Daniel D. Borgeson</name></author><author><name sortKey="Therneau, Terry M" sort="Therneau, Terry M" uniqKey="Therneau T" first="Terry M" last="Therneau">Terry M. Therneau</name></author><author><name sortKey="Rodeheffer, Richard J" sort="Rodeheffer, Richard J" uniqKey="Rodeheffer R" first="Richard J" last="Rodeheffer">Richard J. Rodeheffer</name></author><author><name sortKey="Gabriel, Sherine E" sort="Gabriel, Sherine E" uniqKey="Gabriel S" first="Sherine E" last="Gabriel">Sherine E. Gabriel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9539EEC03D4CB37393D1C78B7D73FB3CC7FBEC37</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1136/ard.2009.124362</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-M0ZVR43J-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002973</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002973</idno><idno type="wicri:Area/Istex/Curation">002973</idno><idno type="wicri:Area/Istex/Checkpoint">000586</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000586</idno><idno type="wicri:doubleKey">0003-4967:2010:Liang K:increased:prevalence:of</idno><idno type="wicri:Area/Main/Merge">001644</idno><idno type="wicri:Area/Main/Curation">001641</idno><idno type="wicri:Area/Main/Exploration">001641</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Increased prevalence of diastolic dysfunction in rheumatoid arthritis</title><author><name sortKey="Liang, Kimberly P" sort="Liang, Kimberly P" uniqKey="Liang K" first="Kimberly P" last="Liang">Kimberly P. Liang</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Division of Rheumatology, University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Myasoedova, Elena" sort="Myasoedova, Elena" uniqKey="Myasoedova E" first="Elena" last="Myasoedova">Elena Myasoedova</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Crowson, Cynthia S" sort="Crowson, Cynthia S" uniqKey="Crowson C" first="Cynthia S" last="Crowson">Cynthia S. Crowson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Davis, John M" sort="Davis, John M" uniqKey="Davis J" first="John M" last="Davis">John M. Davis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roger, Veronique L" sort="Roger, Veronique L" uniqKey="Roger V" first="Véronique L" last="Roger">Véronique L. Roger</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Diseases, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Karon, Barry L" sort="Karon, Barry L" uniqKey="Karon B" first="Barry L" last="Karon">Barry L. Karon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Diseases, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Borgeson, Daniel D" sort="Borgeson, Daniel D" uniqKey="Borgeson D" first="Daniel D" last="Borgeson">Daniel D. Borgeson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Diseases, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Therneau, Terry M" sort="Therneau, Terry M" uniqKey="Therneau T" first="Terry M" last="Therneau">Terry M. Therneau</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rodeheffer, Richard J" sort="Rodeheffer, Richard J" uniqKey="Rodeheffer R" first="Richard J" last="Rodeheffer">Richard J. Rodeheffer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Diseases, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gabriel, Sherine E" sort="Gabriel, Sherine E" uniqKey="Gabriel S" first="Sherine E" last="Gabriel">Sherine E. Gabriel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2010-09">2010-09</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1665">1665</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Antirheumatic drugs</term><term>Arterial pressure</term><term>Arthritis</term><term>Arthritis rheum</term><term>Atrial</term><term>Atrial contraction</term><term>Atrial volume index</term><term>Biological agents</term><term>Blood pressure</term><term>Clin</term><term>Clin rheumatol</term><term>Cohort</term><term>Congestive heart failure</term><term>Diabetes mellitus</term><term>Diastolic</term><term>Diastolic blood pressure</term><term>Diastolic dysfunction</term><term>Diastolic function</term><term>Diastolic function abnormalities</term><term>Disease characteristics</term><term>Dmards</term><term>Doppler</term><term>Drug usage</term><term>Dysfunction</term><term>Echocardiographic</term><term>Echocardiography</term><term>Echocardiography visit</term><term>Further investigation</term><term>Heart failure</term><term>Higher prevalence</term><term>Hypertension</term><term>Lling</term><term>Lling pressures</term><term>Lling velocity</term><term>Mass index</term><term>Mayo</term><term>Mayo clinic</term><term>Mayo clinic college</term><term>Methotrexate</term><term>Mitral peak</term><term>Myocardial function</term><term>Ndings</term><term>Olmsted county</term><term>Other dmards</term><term>Previous studies</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatol</term><term>Risk factors</term><term>Tricuspid regurgitant</term><term>Vast majority</term><term>Ventricular</term><term>Ventricular function</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To compare the prevalence of left ventricular (LV) diastolic dysfunction in subjects with and without rheumatoid arthritis (RA), among those with no history of heart failure (HF), and to determine risk factors for diastolic dysfunction in RA. Methods A cross-sectional, community-based study comparing cohorts of adults with and without RA and without a history of HF was carried out. Standard two-dimensional/Doppler echocardiography was performed in all participants. Diastolic dysfunction was defined as impaired relaxation (with or without increased filling pressures) or advanced reduction in compliance or reversible or fixed restrictive filling. Results The study included 244 subjects with RA and 1448 non-RA subjects. Mean age was 60.5 years in the RA cohort (71% female) and 64.9 years (50% female) in the non-RA cohort. The vast majority (>98%) of both cohorts had preserved ejection fraction (EF≥50%). Diastolic dysfunction was more common in subjects with RA at 31% compared with 26% (age and sex adjusted) in non-RA subjects (OR=1.6; 95% CI 1.2 to 2.4). Patients with RA had significantly lower LV mass, higher pulmonary arterial pressure and higher left atrial volume index than non-RA subjects. RA duration and interleukin 6 (IL-6) level were independently associated with diastolic dysfunction in RA even after adjustment for cardiovascular risk factors. Conclusion Subjects with RA have a higher prevalence of diastolic dysfunction than those without RA. RA duration and IL-6 are independently associated with diastolic dysfunction, suggesting the impact of chronic autoimmune inflammation on myocardial function in RA. Clinical implications of these findings require further investigation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Liang, Kimberly P" sort="Liang, Kimberly P" uniqKey="Liang K" first="Kimberly P" last="Liang">Kimberly P. Liang</name></region><name sortKey="Borgeson, Daniel D" sort="Borgeson, Daniel D" uniqKey="Borgeson D" first="Daniel D" last="Borgeson">Daniel D. Borgeson</name><name sortKey="Crowson, Cynthia S" sort="Crowson, Cynthia S" uniqKey="Crowson C" first="Cynthia S" last="Crowson">Cynthia S. Crowson</name><name sortKey="Davis, John M" sort="Davis, John M" uniqKey="Davis J" first="John M" last="Davis">John M. Davis</name><name sortKey="Gabriel, Sherine E" sort="Gabriel, Sherine E" uniqKey="Gabriel S" first="Sherine E" last="Gabriel">Sherine E. Gabriel</name><name sortKey="Gabriel, Sherine E" sort="Gabriel, Sherine E" uniqKey="Gabriel S" first="Sherine E" last="Gabriel">Sherine E. Gabriel</name><name sortKey="Karon, Barry L" sort="Karon, Barry L" uniqKey="Karon B" first="Barry L" last="Karon">Barry L. Karon</name><name sortKey="Myasoedova, Elena" sort="Myasoedova, Elena" uniqKey="Myasoedova E" first="Elena" last="Myasoedova">Elena Myasoedova</name><name sortKey="Rodeheffer, Richard J" sort="Rodeheffer, Richard J" uniqKey="Rodeheffer R" first="Richard J" last="Rodeheffer">Richard J. Rodeheffer</name><name sortKey="Roger, Veronique L" sort="Roger, Veronique L" uniqKey="Roger V" first="Véronique L" last="Roger">Véronique L. Roger</name><name sortKey="Roger, Veronique L" sort="Roger, Veronique L" uniqKey="Roger V" first="Véronique L" last="Roger">Véronique L. Roger</name><name sortKey="Therneau, Terry M" sort="Therneau, Terry M" uniqKey="Therneau T" first="Terry M" last="Therneau">Terry M. Therneau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001641 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001641 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9539EEC03D4CB37393D1C78B7D73FB3CC7FBEC37
|texte= Increased prevalence of diastolic dysfunction in rheumatoid arthritis
}}
| This area was generated with Dilib version V0.6.33. |  |